The Gradebook can reveal potentially questionable student behavior.
Students who consistently don't submit work may have dropped the course. (These accounts may also have become phantom students, a possible cheating method.)
You can check how long students spend on an assignment by displaying the Time tab or by exporting times or difficulty ratings. Students who may be cheating may spend a very short time on answers and may do very well.
From the Gradebook you can drill down to see a student's work on an individual assignment, including any item, item part, or individual answer. Examining the individual work of multiple students can reveal patterns of possible answer sharing. Time of submission can also be important.